Candida albicans proteinases

نویسندگان

  • Braz J Oral
  • Rita de Cássia Mardegan
  • Mary Ann Foglio
  • Reginaldo Bruno Gonçalves
  • José Francisco Höfling
چکیده

Rita de Cássia Mardegan1 Mary Ann Foglio2 Reginaldo Bruno Gonçalves3 José Francisco Höfling4 1DDS, MSc, Graduate Student at the University of Campinas – Piracicaba Dental School Department of Oral Diagnosis, São Paulo, Brazil 2DDS, PhD, Professor Research Center for Chemistry, Biology and Agriculture (CPQBA) Department of Phytochemical, University of Campinas, São Paulo, Brazil 3DDS, PhD, Professor at the University of Campinas Piracicaba Dental SchoolDepartment of Oral Diagnosis, São Paulo, Brazil,. 4BS, MS, PhD, Professor at the University of Campinas Piracicaba Dental School Department of Oral Diagnosis, São Paulo, Brazil.

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منابع مشابه

Role of Aspartic Proteinases in Candida Albicans Virulence. Part I. Substrate Specificity of Aspartic Proteinases and Candida Albicans Pathogenesis Rola Proteazy Aspartylowej W Wirulencji Candida Albicans Część I. Specyficzność Substratowa Proteazy Aspartylowej a Patogeneza Zakażeń Candida Albicans

Candida albicans resides mainly as a harmless commensal in the gastrointestinal tract, vagina and some cutaneous areas of humans. However, in individuals who are immunocompromised or debilitated in some other way, C. albicans is responsible for superficialy-localized or systemic infections. Candida albicans produces a large family of secreted aspartyl proteinases (Saps) which are key virulence ...

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Role of Aspartic Proteinases in Candida Albicans Virulence. Part Ii: Expression of Sap1-10 Aspartic Proteinase during Candida Albicans Infections in Vivo Rola Proteazy Aspartylowej W Wirulencji Candida Albicans Część Ii: Ekspresja Sap1-10 Proteazy Aspartylowej Podczas Zakażeń Candida Albicans in Vivo

Candida albicans is an opportunistic fungal pathogen known to produce several secreted hydrolytic enzymes, among which aspartic proteinases are considered to be a key virulence factor in pathogenesis. During last decade, Saps have been extensively studied in several in vivo studies based on human samples and animal models. It has been demonstrated that SAP5 and SAP9 are the most highly expresse...

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Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.

Candida albicans is the most common fungal pathogen of humans and has developed an extensive repertoire of putative virulence mechanisms that allows successful colonization and infection of the host under suitable predisposing conditions. Extracellular proteolytic activity plays a central role in Candida pathogenicity and is produced by a family of 10 secreted aspartyl proteinases (Sap proteins...

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Three distinct secreted aspartyl proteinases in Candida albicans.

The secreted aspartyl proteinases of Candida albicans (products of the SAP genes) are thought to contribute to virulence through their effects on Candida adherence, invasion, and pathogenicity. From a single strain of C. albicans (WO-1) which expresses a phenotypic switching system, three secreted aspartyl proteinases have been identified as determined by molecular weight and N-terminal sequenc...

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Characterization of a secretory proteinase of Candida parapsilosis and evidence for the absence of the enzyme during infection in vitro.

The opportunistic yeastlike fungi of the genus Candida comprise three species which are proteolytic in vitro. Among them, C. albicans and C. tropicalis are of foremost medical importance. However, a strict correlation between extracellular proteolytic activity and virulence is opposed by the low virulence of the third proteolytic species, C. parapsilosis. We purified the secretory acid proteina...

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تاریخ انتشار 2006